The Definitive Guide to ceesdekker
The Definitive Guide to ceesdekker
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Halfway as a result of his career, Cees Dekker reinvented himself. Immediately after many years of hardcore physics, he shifted his aim to ‘nanobiology’ on the transform from the millennium. A phrase he coined himself, to be a issue of actuality.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Our function was swiftly followed up by Other folks, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 revealed their results on transistors made out of solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review in the dynamics DNA supercoils and the invention of supercoil hopping
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
‘At the outset we looked at biological programs which has a physical check out and acted on The premise of your resources we understood. It took a several years before we started out Functioning far more on the massive Organic issues. I then started to get in touch with it nanobiology, a expression that didn't exist at the time.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
‘Sure, I have an understanding of folks were being shocked at some time. At the end of the nineties, Once i was in my forties, I was Professor of Molecular Electronics and I have to confess that it experienced become a little bit bored, I didn’t study A lot anymore. The sphere went a lot more into the applying facet, how you may combine nanotubes into electronic circuits.
Right now, we also recognized that it should be achievable to work with an individual semiconducting carbon nanotube to generate a transistor — and we set out to make it. We stretched person semiconducting nanotubes throughout metallic electrodes and made cees dekker use of the fundamental silicon substrate for a gate electrode, developing The fundamental three-terminal layout of a industry-influence transistor (Fig.
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2001, discovery of single-electron transistors at area temperature determined by nanotubes; realization of initially logic circuits with carbon nanotube equipment; and discovery of your molecular construction of DNA fix enzymes with AFM
Permit’s to start with look back in the meanwhile any time you made a decision to change your aim from superconductivity and nanotubes to biology at the conclusion of the nineteen nineties.
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and single-molecule experiments